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Nov 14, 2010 - Nov 18, 2010 Booth 612 New Orleans, LA USA |
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| Contact METTLER TOLEDO |
The American Association of Pharmaceutical Scientists is dedicated to being the premier organization of all scientists dedicated to the discovery, development and manufacture of pharmaceutical products and therapies through advances in science and technology. Thousands of pharmaceutical scientists from around the world will gather in New Orleans as the 2010 AAPS Annual Meeting will be held in conjunction with the International Pharmaceutical Federation’s (FIP) Pharmaceutical Sciences World Congress (PSWC).
METTLER TOLEDO will attend the 2010 AAPS Annual Meeting to discuss various aspects of collaborative research carried out with a number of pharmaceutical scientists from industry. Our Process Analytical Technologies (PAT) for the in-process monitoring of particles and droplets are used extensively in the research, development and scale-up of drug product formulations.
Below is an extensive list of previous AAPS presentations highlighting how pharmaceutical scientists use METTLER TOLEDO PAT technology to further their research and optimize their manufacturing processes using the principles of Quality by Design (QbD). Many of these papers are also available for download. Please contact us if you would like any additional information or if you would like to meet with us at the 2010 AAPS Annual Meeting in New Orleans. Hope to see you there.
- A Real-time Study of Disintegration and Dissolution in Solid Oral Dosage Forms with Focused Beam Reflectance Measurement (FBRM®) Technology - Abbott Labs PPD R&D (2009)
- Roller Compaction Process Optimization using FBRM® At-line Particle Characterization Monitoring and Control - Patheon (2009)
- Formulation Strategies for a Poorly Soluble Drug Molecule Using Liquid Filled Capsules: From Enhancing Solubility to Sustaining Supersaturation - Amgen Inc. (2009)
- Application of Focused Beam Reflective Measurement (FBRM®) and Process Video Microscopy (PVM®) in Formulation Screening - Novartis Pharmaceuticals (2009)
- Quality by Design (QbD): A Design of Experiments (DOE) Approach to Examine the Effects of Process Variables on Particle Size Distribution for a Pharmaceutical Co-precipitation Process via a Real-Time Process Monitoring Strategy - Food and Drug Administration (FDA) (2009)
- Scale-up and Optimization of a Fluid Bed Coating Process Real-time Particle Monitoring and Control - GEA Niro and Bristol-Myers Squibb (2008)
- Understanding Dissolution Inconsistency In Situ Disintegration Mechanisms - Distek (2008)
- Wet Granulation Scale-up and Control with In Situ Particle Characterization - GEA Pharma Systems (2008)
- High Shear Wet Granulation Processes with In Situ Particle Characterization - GlaxoSmithKline (2008)
- Determination of Granulation Growth Rates: A Comparison between FBRM® and Sieve Analysis - Purdue University (2007)
- Use of Focused Beam Reflectance Measurement (FBRM®) To Monitor Drug Dissolution in Microemulsion Preconcentrates - Novartis (2007)
- Development of a Method for Measuring Particle Size Distribution in Real Time during Disintegration - Amgen, Inc. (2007)
- In-vitro Selection of Excipients to Enhance the In Vivo Solubility of a Poor Solubility Drug From a Conventional Solid Oral Dosage Form - Merck and Co, Inc. (2007)
- Investigation of an Atypical Observation of Harder Tablets Having a Faster Dissolution Rate - GlaxoSmithKline (2007)
- Effect of Chloride Ion and ph on the Dissolution of An Amine Derivative - Wyeth (2007)
- Mass and Heat Balance in Fluid Bed Spray Granulation - Johnson and Johnson (2006)
- Effect of Process Variable on Fluid Bed Coating - Inline Monitoring of Pellet Size, Growth and Population - Forest Laboratories, Inc. (2006)
- Understanding Hydrate Formation During Wet Granulation - Purdue University and University of Copenhagen (2006)
In 2010, visit Booth 612 at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting to see the latest METTLER TOLEDO particle size distribution technologies on display, including:
NEW for 2010 – C35 Atex – Check back for additional updates
V819 with PVM® Technology - In-Process Video Microscopy
The new generation PVM® was developed to enable significantly improved understanding of particulate processes. PVM® technology provides in-process high resolution images, confirming shape and dimension for particles, cells, droplets, and bubbles ranging from 2μm to 1000μm.
After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle/droplet size, shape, and count characterization.
Related topics: AAPS, American Association of Pharmaceutical Scientists, formulations, particle size distribution, QbD, Quality by Design, PAT, Process Analytical Technology, liquid dosage formulation, particle dimension, particle shape, particle count, FBRM, PVM, formulation development, granule size, in-line particle characterization
NEW for 2010 – C35 Atex – Check back for additional updates
FBRM® C35 - Measure Particle Distribution In-Process
Granule or particle size is a critical parameter in high shear wet granulation. Formulators and engineers can reduce development time up to 50% with FBRM® real-time granule size monitoring while targeting a particle size distribution providing uniform flow properties and tablet dissolution profiles. FBRM® in-line particle characterization can optimize and control batch-to-batch repeatability upon scale-up from the lab to the plant and ensure batches do not fail size specifications.
Granule or particle size is a critical parameter in high shear wet granulation. Formulators and engineers can reduce development time up to 50% with FBRM® real-time granule size monitoring while targeting a particle size distribution providing uniform flow properties and tablet dissolution profiles. FBRM® in-line particle characterization can optimize and control batch-to-batch repeatability upon scale-up from the lab to the plant and ensure batches do not fail size specifications.
V819 with PVM® Technology - In-Process Video Microscopy
The new generation PVM® was developed to enable significantly improved understanding of particulate processes. PVM® technology provides in-process high resolution images, confirming shape and dimension for particles, cells, droplets, and bubbles ranging from 2μm to 1000μm.
After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle/droplet size, shape, and count characterization.
Related topics: AAPS, American Association of Pharmaceutical Scientists, formulations, particle size distribution, QbD, Quality by Design, PAT, Process Analytical Technology, liquid dosage formulation, particle dimension, particle shape, particle count, FBRM, PVM, formulation development, granule size, in-line particle characterization